Abnormality of dominant oncogenes and recessive oncogenes in human bone and soft tissue tumors
نویسندگان
چکیده
منابع مشابه
Activation of proto-oncogenes in human and mouse lung tumors.
Lung cancer is a leading cause of cancer-related deaths in several nations. Epidemiological studies have indicated that 85% of all lung cancer deaths and 30% of all cancer deaths in the U.S. are associated with tobacco smoking. Various chemicals in tobacco smoke are thought to react with DNA and to ultimately yield heritable mutations. In an effort to understand the molecular mechanisms involve...
متن کاملDifferent expression patterns of oncogenes and proto-oncogenes in hereditary and carcinogen-induced tumors of Xiphophorus.
Hereditary melanoma in Xiphophorus hybrids carrying the melanoma-inducing Tu-Sd locus is caused by transcriptional activation of the Xmrk gene that resides at the Tu-Sd locus and encodes a novel member of receptor tyrosine kinases (RTK). In this study, a total of 27 hereditary melanomas from various hybrid genotypes harbouring 7 different Tu alleles were also found to over-express the correspon...
متن کاملOncogenes and anti-oncogenes in tumorigenesis.
Recent advances have led to the identification of cellular genes which are involved in the initiation and progression of tumorigenesis. The proto-oncogenes, which normally participate in the regulation of cell proliferation and differentiation, can become oncogenes through alterations in the regulation of their expression and/or their coding sequences. Their contribution to the tumorigenic phen...
متن کاملRetroviral and human cellular oncogenes.
Unexpected meeting of two separate lines of research resulted in the discovery of oncogenes. Oncogenes are deoxyribonucleic acid (DNA) sequences coding for polypeptide gene products which cause, or contribute to, neoplastic growth of cells. Oncogenes remain almost unchanged through evolution: oncogenes and their gene products of avian, murine, feline, simian and human species show close homolog...
متن کاملGTP-binding proteins as oncogenes in human tumors.
Ras oncogenes are the most commonly known oncogenes in human tumors; their prevalence in different types of tumors and their role in the development of these tumors have been discussed in recent reviews (1,2). We have investigated the biochemical mechanism that accounts for the activation of ras proto-oncogenes to become oncogenes. In normal cells, the ras p21 cycles between the active guanosin...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Okayama Igakkai Zasshi (Journal of Okayama Medical Association)
سال: 1989
ISSN: 0030-1558,1882-4528
DOI: 10.4044/joma1947.101.5-6_589